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  TOPIC OF THE MONTH

Dr.P.A.Nazeem

Professor & Coordinator, DIC

Genesis

The Bioinformatics Centre at KAU runs under the Biotechnology Information System Network (BTISnet) programme, of DBT, Government of India. The Centre was upgraded to DIC [Distributed Information Centre] during 2004 to support Plant Biotechnology research. Major activities of the centre are listed below:

As a supporting centre for Biotechnology  

The Centre was shifted to new premises in September 2006 which also has facilities for wet lab work. Following facilities are available at the Centre:

•  Database querying

•  Sequence analysis

•  Primer designing

•  Molecular visualization & Docking

•  PCR analysis

•  Gel Documentation for Molecular Marker Data.

 Research Highlights
 The main area of specialization is Plant Biotechnology. Apart from acting as a supporting centre for Biotechnology research, the Centre is involved in creating databases relevant to agriculture like SpicesInfo and RiceInfo. Other In Silico projects that are carried out include:
 ● Predicting functionally important residues in cysteine proteinases involved in programmed cell death of plants
 ● A tool for the analysis of variation of amino acids in the conserved domains of proteins
 ● An evolutionary and structural analysis of Auxin Response Factor
 ● Imperativeness of Coronatine-Insensitive 1 protein in Jasmonate signaling mechanism: A computational biology scenario

Ongoing Projects

Successfully Completed Projects
2008-09
 ● Computational approaches for a Novel Drug from Piper nigrum against Lung cancer. Shidhi P.R
 ● Study of antiviral properties of eupatorium odoratum against chikungunya virus:                                                      A computational approach - Sreejisha P.S
 ● Anti-Cancer Drug Discovery: Plant phytochemicals as Candidate Anti-Cancer Compounds - Emma Jose
 ● A Computational Approach to Evaluate the Efficacy of Natural Antioxidants in Type II Diabetes Remya .C.Venu
 ● Novel target and Emerging remedies for Alzheimer’s disease Nancy Thomas
2007-08
 ● In silico approach to alleviate parkinson’s disease using plant derived compounds - Alishya Joy
 ● Virtual Screening for novel inhibitors against Bacterial Blight of Rice - Reena.N
 ● In silico study of antimicrobial properties of Ginger against Epstein-Barr virus, Aspergillus flavus and        Helicobacter pylori.
 ● In silico analysis of Insulin like proteins in plants - Reena.N
 ● Bioprospecting of Mycolytic Microorganisms focalizing on Chitin Binding Protein (CPB21) of Serratia marcescens by  studying its binding properties in Chitin degradation - Abhilash Joseph
 ● A Tool for the data coding of genetic finger printing studies
 ● Inhibitors for ferric dicitrate transport (FecA) protein of Pseudomonas aeruginosa
 ● Imperativeness of Coronatine-Insensitive 1 protein in Jasmonate signaling mechanism: A computational biology scenario
 ● An evolutionary and structural analysis of Auxin Response Factor
 ● A tool for the analysis of variation of amino acids in the conserved domains of proteins
 ● Predicting functionally important residues in cysteine proteinases involved in programmed cell death of plants
2005-06
 ● A comparative study of virulence proteins in Agrobacterium tumefaciens.
 ● Molecular characterization of HMGR gene from Solanaceous plants
 ● Database on Indian Spices
 ● In silico analysis of metabolic enzymes in medicinal plants

Databases Created

SpiceInfo: A database on Indian spices offering CD-ROM search facility is being built using DHTML and JAVA programming. The fields available in the database include Scientific name, Common name, Morphology, Varieties, Soil and climate, Crop establishment, Disease management, Harvesting, Processing and marketing.

RiceInfo: A genetic Database on Rice: 3 divisions

• General: Taxonomic data, Status in Kerala.

• Biotechnology: Data on Varieties, Hybrids, Molecular Breeding, Data on Genetic transformation in rice and Current research work.

• Bioinformatics: Genome and Proteome annotated data and Links to tools for data analysis

Training

The Centre has been successful in creating awareness of Bioinformatics in the field of biological sciences amongst the scientists and students of the Institute through organization of Training programmes on different aspects of Bioinformatics. Bioinformatics awareness fosters the growth of Biocomputing and allied disciplines like Genomics and Proteomics.

Bibliographic Support

The Centre provides CD-ROM search facility for databases acquired like DERWENT, AGRISEARCH, AGRICOLA etc. The centre has created databases on Indian Spices and Rice.

Web-Portal Development

The Centre is updating its portal which can be accessed at www.kaubic.in. The centre has an established 20Mbps leased line internet connectivity from AIRTEL.

 Facilities

 Scientific Software Packages

 Computer and Communication facilities

• Total no. of Computer Systems: 24
• 20 Mbps leased line internet connectivity

• Zip drive

• LCD Projector (2 No.)

• Fax Machine

• Reprographic facilities: Printers, scanners and photostat machine.

National Seminar organized

• ICAR sponsored Winter School (21 days) on “Bioinformatics and its Applications in Agriculture”  was organized from December1st -21st, 2009.

          Twenty five scientists from various national institutes and SAUs all over India participated

• NAIP sponsored Training Programme (15 days) on “Bioinformatics and its Applications in Agriculture”  was organized from May 2^nd -16^th, 2009.

          Sixteen scientists from various national institutes and SAUs all over India participated

Contact Address

Dr. P.A.Nazeem

Professor & Coordinator,

Bioinformatics Centre,

College of Horticulture, KAU P.O.,

Vellanikkara,

Thrissur, Kerala.

PIN 680656

Ph: 0487-2371994

Fax: 914872371994

Email: kaubioinfo@gmail.com, kauniv.btisnet@nic.in, nazeem.pa@kau.in

Website: www.kaubic.in 

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